L-精氨酸生产工艺设计改111

兰州交通大学毕业设计（论文）L-精氨酸生产工艺设计摘要L-精氨酸是人体和动物体内的半必需氨基酸，也是生物体尿素循环的一种重要的中间代谢物。L-精氨酸在医药方面、保健饮品方面、畜牧业方面都具有广泛的应用。本设综述了L-精氨酸的应用和发展，设计了年产150tL-精氨酸的工艺流程，比较了弱酸性兰州交通大学毕业设计（论文）阳离子树脂和DR1树脂提取L-精氨酸的优缺点。以原有的生产工艺为基础，本次设计采用发酵法，以淀粉为原料，以玉米浆为辅料，以黄色短杆菌为生产菌种，最主要的是在下游提取工艺中，采用DR1树脂提取L-精氨酸，提取效率较高。本设计以年产150t吨L-精氨酸的生产规模，列举了生产工艺流程图，进行了物料衡算和设备选型和发酵罐和种子罐的尺寸，分析比较了弱酸性阳离子树脂和DR1树脂提取L-精氨酸两种工艺的经济效益，得出了DR1树脂提取工艺优于弱酸性阳离子树脂提取工艺。关键词：L-精氨酸，发酵法，提取，工艺设计兰州交通大学毕业设计（论文）AbstractL-arginineisasemi-essentialaminoacidsinthehumansandanimals,Isalsoanimportantintermediateoftheureacycleandmetabolismoforganisms.L-argininehasanextensiveapplicationinmedicine,healthdrinkandthelivestockindustry.Thissetgaveanoverviewofdevelopmentandapplicationofl-arginine,Designingaproductioncapacityof150tL-arginineprocess,Comparedwithweakacidcation-exchangeresinextractionofL-arginineandDR1resinadvantagesanddisadvantagesThedesignusesafermentationmethodwithstarch,cornsyrupasadjunct,fortheproductionofbrevibacteriumflavumstrain,Mostnotablyinthedownstreamextractionprocess,DesingDR1toextracL-argininetogetahighextractionefficiency.Designascaleofproductiontoget150tL-arginine.Istingaproductionofflowchart,thematerialbalanceandtheselectionofequipment,andthesizeoffermentationtankandseedtankaredesigned,Analysingandcomparingtwokindsofprocessesofextractionofl-arginineaboutacidcation-exchangeresinandDR1resinstatistics,wecanseetheDrewDR1resinextractiontechnologyissuperiortoweakacidcation-exchangeresinextractionprocess.Keywords:L-arginine,Fermentation,Extraction,Adesignedprocess兰州交通大学毕业设计（论文）II目录1绪论...........................................................................................................................................................I1.1L-精氨酸的结构与性质....................................................................................................................11.1.1L-精氨酸的结构.....................................................................................................................11.1.2L-精氨酸的性质.....................................................................................................................11.2L-精氨酸的功能................................................................................................................................11.3L-精氨酸的应用................................................................................................................................11.3.1L-精氨酸在医药方面的应用.................................................................................................11.3.2L-精氨酸在保健饮品方面的应用.........................................................................................31.3.3L-精氨酸在畜牧业方面的应用.............................................................................................31.3.4L-精氨酸在其他方面的应用.................................................................................................31.4L-精氨酸发酵的研究及生产现状....................................................................................................41.4.1国外L-精氨酸发酵的现状....................................................................................................41.4.2国内对L-精氨酸发酵的研究及生产现状............................................................................41.5L-精氨酸的生物合成途径及生产方法............................................................................................41.5.1生物合成途径.........................................................................................................................41.6L-精氨酸的提取过程........................................................................................................................61.6.1L-精氨酸的提取流程.............................................................................................................61.6.2L-精氨酸吸附洗脱过程常用树脂及材料.............................................................................72工艺流程及工艺流程论证........................................................................................................................92.1发酵法生产L-精氨酸......................................................................................................................92.2发酵法生产L-精氨酸工艺流程......................................................................................................92.3发酵菌种与培养基原料.................................................................................................................102.3.1发酵菌种和发酵周期..........................................................................................................102.3.2培养基的原料......................................................................................................................102.4工艺流程的论证.............................................................................................................................102.4.1发酵过程的控制..................................................................................................................102.4.2发酵条件的控制..................................................................................................................112.4.3L-精氨酸的生物合成部分的方程式.....................................................................