异丙醇的毒性

()199。113.129·(isoppalCOho],isop`opanol,IPA),CH3CHOCH3。。1,。、,、。2,。60.1;0.79(20℃/4℃);89.5℃;82.4℃;89.5℃;11.7℃;5.87kP。(25℃);2、12。〔13〕。3。、,”〕。3.13.1.11。1,。、、、、。`,24,4001。。5500pp:::。400pp`,2;5500ppn,2〔5〕。3,1.2Anes14.7~.849/kgLC(sh)16oooppm4/65.7。.239/kgLD601.80.239/kgLD4.81.809/kgLDoo1.280.619/kgLDoo`zZomn)0.020390.0036Rg/1LDoo2.5ml/kg3.35ml/g5.12ml/kg16.4ml/kgLD6o,J......................5959。300oppm3、7h/d,5、8,2.5,〔“〕。12233,3,8,,2.6nlg/(g·d)6.4。g,(/L.gd)6,、,(B.S.P)。166ml。。3,2156mg/100ml157mg/looml,3()199。113405mg/lo0lm,、3。75(),15。,(hem。。-binurienephrosis),,,。.,.l2(20omg/looml)。,、、,,.3.2.2Zooppnr;400ppm、,800ppm。(permissibleexposurelimit,PEI)400ppm(gsom“),(imnrediatelydangeroustolifeorhealth,IDHL)20000ppm.,L,()。。,,.,。、〔7。,,、,,〔1。〕.3.2.3、、、、,。,、。4、,,,。,。,。’,。〔”〕。90ml,:、、、、。,1/2〔2〕。2〔11,12〕ppmmg/m3OSHA(1976)shNiOSH(1976)10h15inACGIH(1981)(195)(1985)(1986)sh10min(1969)(1975)(193)(1975)TLVTWA400TLVTWA400STEL800TLV400STEI500TLV200STEI300MACMAK400TLVTWA400STEI500MAC200MAC160MAC80TLV4009809841968980122508070010()980980()1225()500()199。113131~~~~..,~~+`,~,....r,。n:、、、、、、、、、、。99.99%。o.GI%,、、、、、、、、、、、。,、、、,,。.10.002.D]O,(DNARNA),..,,、,。、、。、、.,。152.9ppm,、81.oppm,。,,。、。2.37:,120.259(0.2589)0.0819,10.9].2。,..2。6〕..1J.:`197:13.〔.().1J.:,1977:506。〔31P}u:k。tER.Handbookindustraltoxieology.。;Ne`Y。`1:Chemicalpublisilingco,1976·)W`laoWW,e,a、.Alco015,ox`eoogy·NoWJ.rse:oyesDataCo,1983.45.〔5〕YosliihiroOilash;,eal.EvronReseaeh1988;46:25。6〕.:,1988:238.(7〕Jou·fangDeng,etal.AerJournalofIildus-trialMed1987,12:11.〔s〕FollandSD,etal.JAMA1976,236:1855.〔9〕TreigerGJ,etal.rehEnvironHealt}219,28:276。〔1。〕TraigerGJ,etal.ApplPharmaeol1971,12:105。〔11〕NIOSH/OSHA.Oeeupationalealthguidlineforisopropylaleoholinoeeupationalhealthguidlineforehemiealbazards.US。DHHS.1981。〔ACGIH.sopopylaleoholiudooumea。。heTLV.Ohio.1980:239,