22甲基吡嗪的合成工艺改进

164200512JournalofChinaJiliangUniversityVol.16No.4Dec.2005100421540(2005)04203252032005207203(1978),,,..221,2,3(1.310018;2.,3100273.,510180)1,2222.,KB2207.380,8216%.;;1,22;22O643.32+1;TQ460.4AStudyonthesynthesisof22methylpyrazineZHENJie1,ZHAOGui2cai2,CHENxin3(1.CollegeofLifeSciences,ChinaJiliangUniversity,Hangzhou310018,China;2.CollegeofMaterialsScienceandChemicalEngineering,ZhejiangUniversity,Hangzhou310027,China;3.GuangdongInstituteforDrugControl,Guangzhou510180,China)Abstract:Thisprocessstudiesapreparing22methylpyrazinebyvapor2gasphaseheterogeneouscatalyticdehy2dration2dehydrogenationreactionofethylenediaminewithpropyleneglycol.Bychangingtheeffectsofactivecomponents,carrygasandtheratioofwaterinmaterialssystematically,itisconfirmedthatKB2207isanef2fectiveandselectivecatalyst.Thecatalystisusedat380withayieldof8216%.Keywords:catalyst;ethylenediamine;propyleneglycol;22methylpyrazine22,,[1];,22[2].22[3,4].22[5],[6],[7][8].,KB2207.,KB220722.1;1,22;;;;;;;.©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.;1022G.KB2207,,CuO41126%,ZnO41.79%,Al2O37.75%,ZnCu=1.011,193N/cm,12.2g/100ml,1018.22.11,22,,:CH3CHCH2OHOH+CH2NH2CH2NH2NNCH32.22.2.1Cu2Cr2Ba2O37.8,169ml,,.65g,7.8g,225ml,.,,,7580,,10%,,350,3mm.2.2.2Cu2Zn2Ba2O32.1g,118.7g,11.5g,400ml,,200ml28%,,,7580.,350,.2.3,.1,2211,,,.2.4:,,G.D.X2102,160,210.33.1KB2207,1:1/%/%/%/%038.485.033.03063.292.858.74075.874.956.85074.968.251.163.276.443.333.1,1,22,.,,.,.,,,.1,,1,22,30%,.,.,.,,,,,.,,,.,,,.1,,,,.3040%,40%.3.2KB2207,2.2/ml/min/%/%/%080.577.162.14086.780.970.26083.775.263.062316©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,.2,,.,,,.,40ml/min,,.3.3KB2207,,3:3//%/%/%34774.989.567.038084.997.382.641084.395.980.83,,,,.,.,,.,.,380.3.43.4.1Cu2Cr2Ba2O4:,.,,,.,,.400,.BaO,L,,.4Cu2Cr2Ba2O//%/%/%36039.063.424.737561.273.945.240569.337.125.73.4.2Cu2Zn2Ba2O5,,.,BaO.ZnOCr2O3Cu2Zn2Ba2OCu2Cr2Ba2O.,.5Cu2Zn2Ba2O//%/%/%34739.029.411.537755.633.118.440066.544.029.341,22,22.KB2207Cu2Zn2Ba2OCu2Cr2Ba2O,KB2207.,KB2207,40%,38082.6%.[1],,,.22[J].,2001,34(5):694-697.[2],,,.2222[J].,2002,19(6):324-325.[3],,,.[P].:,CN85105846,1986-07-09.[4],,,.22()2[J].,2001,18(5):266-268.[5].[M].:,1999.[6],,,.22[J].,2001(3):22-23.[7]SUBRAHMANYAMM,PRADADAR,KULKARNISJ,etal.Synthesisof22methylpyrazineandpyrazineusingN2(2,32dihydroxypropyl)ethylenediamineoverchromitebasedcatalysts[J].IndianJournalofChemistry,1995,34:573-575.[8],,,.22[J].,2003,20(5):266-269.7234,:22©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.