人类NK细胞的亚群及其特征

:1007-8738(2002)06-645-04NK(,710032):2002-05-28;:2002-06-27:,No.39970688:(19782),,,.17,Tel.[phone]Email:[e-mail]:NK;;;:R392.12:A(naturalkillercell,NK),15%NK,NK,CD8CD16CD56CD94NKp46NK[1],NKCD56,NK,,NK1NK7,NKCD16CD56CD57CD69CD94CD96CD158aCD158bCD159aCD161CD162RCD244,CD3-CD56+CD16+[2]CD56NK,,NK90%NKCD56(CD56dim),CD16(KIR),,,10%NKCD56brightCD16dimCD56brightCD16-NK,KIR,,CooperNKCD56brightCD56dim[3]1.1CD56brightNK1.1.1CD942NKG2ANKNK(NKR)MHC2I,CD56brightNKKIR2(ILT22),CD942NKG2A[426]1.1.2IL22RIL22RNKIL22(IL22R),CD56brightNKIL22(IL22R)[7,8],(10-12mol/L)IL22[9,10],IFN2[11]IL22T,CD56brightNKIL22R,NKT[3]IL22/15RIL215CD56brightNK[12]1.1.3c2kitCD56brightNKc2kit,(SCF)CD56brightNK,IL22[13]c2kit,bcl22,CD56brightNK[14]CD56dimNKc2kit,(1101029mol/L)IL22[7,10]1.1.4IL21RIIL218RNKIL21IL210IL212IL215IL218,,IFN2CD56brightNKIL21RIIL218R[15,16\,IL218NKIFN2,[16]1.1.5CD56brightCD56dimNK,CD56brightNKCCR5CCR7CXCR3CXCR4,CX3CR1,CCR124CCR6CCR9CXCR1CXCR2CXCR5CXCR8;CCR7,NK[17]1.1.6L2L2(CD62L)NK[18],NKCD56brightNKL2,IL22IL215TGF2L2;IL212IL210IFN2CD56brightCD56dimNKL2CD56brightNKL2(HEV)L2,NK[18],CD56dimNKL2CCR7,CD62Ldim,HEV,[18]1.1.7CD55CD59CD55CD59GPICD56+CD3-NKCD55CD59,CD3+546ISSN1007-8738(ChinJCellMolImmunol)2002,18(6)©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,CD55CD59CD56brightCD16dim/-NK(CD55brightCD59bright),CD56dimCD16brightNK(CD55dimCD59dim)[19],1.2CD56dimNK1.2.1KIRCD56dimNKKIRILT22CD56brightNK,CD942NKG2A[426]NK,NKR1.2.2CD16CD16IgGFcRIII,(FcRIIIA)GPI(FcRIIIb)NKFcRIIIAADCC[2]95%CD56dimNKCD16(CD16bright);50%70%CD56brightNKCD16,CD16(CD16dim)[20]CD16NKADCC1.2.3CD56dimCD16+NKCXCR1CX3CR1CXCR4,CXCR2CXCR3,CCR127CCR9CXCR5[17]1.2.4PEN5PEN5(CD162R)2N2[21],CD56dimNK,P21(PSGL21),L2[4],CD62L+CD56brightNKPEN52PSGL21+CD56dimNK[3]NKPEN5,,NKPEN5[21]1.2.5LFA21NKLFA21,CD56dimNK,CD56brightNK,[18]1.3CD56brightCD56dimNKNKG2D[22],MHC2IMICAMICBUL216[22,23](NCR)NK,CD16[24]CD56brightNKCD2CD11cCD15sCD44CD49eCD55CD62LHLA2DRGZS21CD56dimNK,CD49f11%CDw65,CD56brightNK,28%CD56brightNKCD45RO[25]NK,CD43,,NKCD56brightNKCD43,CD43O2O2CD56dimNKCD43,CD56brightNKCD43,[26]2NKNK,2.1NK:Ca2+(B);FasLTRAIL,Fas(CD95/Apo21)DR4/DR5;2.1.1//NK,[2]CD56brightCD56dimNK[27],CD56dimNK[28],CTLNKSAPLIP,C[29],NK2.1.2NKFasLmRNA[30]CD161+CD562NKK562,Jurkat,CD56+NK,FasL,FasLmAb,[31],Ca2+[30]CD161+CD562NKTRAIL;CD56+NKFasL[30]CD3-CD3+NKTRAILmRNA;IL22,CD3-CD56+NKTRAIL,Jurkat,FasL[32]2.1.3ADCCCD56dimNKIgGFcRIIIA,CD56brightNKADCC[28]2.1.4NK,NK,NKR,CD56brightCD16dim/2NKrIL22,CD56dimCD16brightNK[19,28],IL22IL212IL22,NK[78,33]IL212NK(B)[34]IL212CD95,NKCD16[35]Valiante,NKKIR;NKCD942NKG2A,KIR[36]646ISSN1007-8738(ChinJCellMolImmunol)2002,18(6)©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.2.2NK,IIIIFN2TNF2GM2CSFLTIL28[37]IL25[38]GM2CSFG2CSFIL21,TNF2IFN2TGF2,NK[39]NKIFN2,Th1IFN2,[40]2.2.1RT2PCRNK,Th1/Th2,NKIFN2,IL210IL213[41]PMANK,CD56brightNK,IFN2LT2GM2CSFIL210IL213;CD56dimNK[42]NKIL21IL212CD56brightNK,PCR,IFN2,,CD56brightNK(42%2.3%)IFN2CD56dimNKIFN2,NK:(5.4%0.9%)IFN2,IFN2,CD56brightNKIL215IL212IFN2,CD56dimNK(8.9%4.0%)IFN2[15]2.2.2NKIL212NKIFN2,IL21IL215IFN2,IL21IL212CD56brightNKIFN2,IL215IL21224IL212IL215CD56brightCD56dimNK72h,IL21[15]IL218IL218RCD56brightNKIFN2[16]NK,IL212IL24mAb(Th1),IFN2GM2CSFTNF2LT;IL24IL212mAb(Th2),GM2CSFTNF2LT,IL25IL213,IFN2[35],IL22IL24,IL22IL24IL214IL215IL29mRNA[35],CD56brightNK,CD56dimNKNK,IL21IL212CD56brightNKIFN2,,CD56dimNKIFN2(15)[15]CD56dimNKII,IL215[42],IL22CD161+CD562NKIFN2[31\,,CD56brightNKIII[3]NK,NK,NK,NKCD56,HLA,,;,,,NKCD56,NK,:[1]LozaMJ,PerussiaB.Finalstepsofnaturalkillercellmaturation:amodelfortype12type2differentiation[J].Natimmunol,2001,10:9172924.[2],.[M].2.:,2001:9.[3]CooperMA,FehnigerTA,CalligiuriMA.Thebiologyofhumannaturalkiller2cellsubsets[J].TrendsImmunol,2001,22:6332640.[4]AndreP,SpertiniO,GuiaS,etal.ModificationofP2selectingly2coproteinligand1withanatural2killer2cell2restrictedsulfatedlac2tosaminecreatesanalternateligandforL2selectin[J].ProcNatlA2cadSciUSA,2000,97:340023405.[5]VossSD,DaleyJ,RitzJ,etal.ParticipationoftheCD94receptorcomplexincostimulationofhumannaturalkillercells[J].JIm2munol,1998,160:161821626.[6]ColonnaM,NavarroF,BellonT,etal.Acommoninhibitoryre2ceptorformajorhistocompatibilitycomplexclassImoleculesonhu2manlymphoidandmyelomonocyticcells[J].JExpMed,1997,186:180921818.[7]CaligiuriMA,ZmuidzinasA,ManleyTJ,etal.Functionalconse2quencesofinterleukin22receptorexpressiononrestinghumanlym2phocytes.Identificationofanovelnatural2killer2cellsubsetwithhigh2affinityreceptors[J].JExpMed,1990,171:150921526.[8]NaglerA,LanierLL,PhillipsJH.Constitutiveexpressionofhigh2affinityinterleukin22receptorsonhumanCD216naturalkillercellsinvivo[J].JExpMed,1990,171:152721533.[9]CaligiuriMA,MurrayC,RobertsonMJ,etal.Selectivemodulationofhumannaturalkillercellinvivoafterprolongedinfusionoflow2dosere2combinantinterleukin22[J].JClinInvest,1993,91:1232132.746ISSN1007-8738(ChinJCellMolImmunol)2002,18(6)©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.[10]BaumeDM,RobertsonMJ,LevineH,etal.Differentialrespons2estointerle