NovelMaterialsforEnergy能源新材料

NearInfrared-IIImaging,PlasmonicPlatforms,GrapheneNanoribbons&NovelMaterialsforEnergyHongjieDaiDepartmentofChemistry,StanfordUniversityOurCurrentResearchNanoCarbon-InorganicHybridmaterialsENERGYCarbonNanotube(CNT)&grapheneNANO-BIOGrapheneNanoribbonNOVEL1DSYSTEMS500nmPlasmonicGoldFilmsInterfaceNanomaterialswithBio-SystemsCarbonNanotube(CNT)&Nano-graphene500nmPlasmonicGoldFilms•Utilizationofthephysical(electrical,optical…)propertiesofnanomaterialsforimaging,detection,diagnosisandtreatmentofdiseases(cancer,heartdisease...)TopFatalDiseases:1.IschaemicheartdiseaseAnnualdeaths:~7,200,0002.CancersAnnualdeaths:~7,100,0003.Cerebrovasculardisease(Stroke)Annualdeaths:~5,500,000Vesseldiseases:#1killer500nmMakingCNTsBiocompatibleandNon-ToxicinPBSinPBS80ºCaNH2NH2NH2PolyethyleneGlycol•Length50-200nm.•Solubleinbuffersandserum.•Antibodiesorpeptidescanbeattached.SWNT/Phospholipid-PEG(PEG)XCNHOPOHOO-OOOOCH2CH2OO45(Kam,N.W.S.etal.PNAS2005,102,11600.)PhotoluminescenceEmissionWavelength(nm)ExcitationWavelength(nm)(6,5)(10,2)(8,7)CarbonNanotubesFluorescenceinNIR-IIResonanceRaman•ExcitedresonantlythroughEiitransitionsin500-900nmrange.•Fluorescein1-1.4mmrange(NIRII);largeStoke’sshift.Weisman&Smalley@RiceSmith,Andrew.M.,Mancini,Michael.C.Nie,Shuming.NatNano2009,4,710.DevelopingOpticalImaginginTheSecondNIRWindow(NIR-II,1-1.4mm)OldNIRwindowAnewwindowSidetectorInGaAsdetectorKevinWelsher,SarahP.Sherlock,andHongjieDai.PNAS.108,8943-8948,2011.ScatteringCoefficient[mm-1]Scatteringl-a:Absorbance:ReducedtissuescatteringinNIR-IINIRINIRIIUntreated30min100nMNIR-IIsignal1000nm–1400nmLittleornoautofluorescenceNIRIIImagingofMiceWelsher,K.etal.NatureNanotechnology;2009WithintravenouslyinjectedSWCNTs:8Deep-TissueNIRIIVideoRateImaging3.5sec3.5seclungslungs17.3sec(c)17.3secliverliver69sec69secspleenspleen5.2sec5.2seckidneykidneysWelsher,K.*,Sherlock,S.*Dai,H.Proc.Nat.Acad.Sci.2011.(Imageintothebodyofamouseoptically)9AnatomicalMappingbyPrincipleComponentAnalysis(PCA)ofNIRIIVideoImagingkidneyliverlungslungsliverkidneyspleenheartspleenlungsspleenlungsliverkidneyspleenkidneykidneyliverpancreaspancreaspancreasWelsher,K.*,Sherlock,S.*Dai,H.Proc.Nat.Acad.Sci.2011.•PCAgroupspixelswithsimilartimevarianceinsignal600800100012001400EmissionofIR800(NIR-I)Emissionofnanotubes(NIR-II)Intensity[a.u.]Wavelength[nm]Absorption01234560.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]0.607mm024680.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]0246810120.00.20.40.60.81.0NormalizedPLintensityPosition[mm]crosssectionprofile1.37mm0123450.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]0.283mm02468100.00.20.40.60.81.0crosssectionprofileNormalizedintensityPosition[mm]0.583mm01234560.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]1cm(f)(g)(h)(l)(m)(n)NIR-IIRdye800NIR-IISWNT1xmagnified(i)(j)(k)(o)(p)5mm1mm(q)1cm5mm1mm2.5xmagnified7xmagnifiedInGaAscamera(NIR-II)Sicamera(NIR-I)mirrorzoomablelenssetSimultaneousImaginginNIR-I&NIRIISWNT+IRDye-800complexNIR-IPeripheralVesselImagingImaginginNIR-IbydetectingIRDye800fluorescence:02468100.00.20.40.60.81.0NormalizedPLintensityPosition[mm]crosssectionprofile024680.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]01234560.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]1cmLowmagMediummagHighmag5mm1mm0123450.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm]024680.00.20.40.60.81.0crosssectionprofileNormalizedintensityPosition[mm]01234560.00.20.40.60.81.0crosssectionprofileNormalizedPLintensityPosition[mm](i)(l)NIR-IINIR-IIPeripheralVesselImagingImaginginNIR-IIbydetectingSWNTfluorescence:G.Hong,J.Lee,J.Cooke,H.Dai,NatureMedicine,20125 mm5 mmNIR-I750-900 nmNIR-II1000-1400 nmNIR-IvsNIR-IIimagingofischemicmousehindlimbNIR-IIImaging:ReducedScatteringG.Hong,J.Lee,J.Cooke,H.Dai,NatureMedicine,2012Previousimagingmodality:micro-CT,MRIClearvs.SmoggyDayinBeijingt=0st=4.98st=10.68st=30.62sPCA(a)(b)(c)(d)(e)aortainferiorepigastricfemoralexternaliliacinferiorepigastricheartaortaepigastricarteryfemoralarteryfemoralveinepigastricveinsiliacfemoral(f)Sub-cmDeepVesselImaging&DifferentiationG.Hong,J.Lee,J.Cooke,H.Dai,NatureMedicine,2012VideoRateImagingofBloodFlowinHealthyvs.IschemicHindlimb(12,1)-enrichedSWNTs103.5s3.1sPCAChiralitySeparatedSWNTforNIR-IIImagingS.Diao,H.Dai,etal.,J.Am.Chem.Soc.2012Gelfiltrationseparationmethod:F.Hennrich,MKappesandcoworkers@KarlsruheInstituteofTechnologyChiralitySeparatedSWNTforTumorPhotothermalTherapyA.Antaris,et.al.,ACSNano,2013•Ultra-lowdosage:~4μgof(6,5)SWCNTspermouse(0.254mg/kg)•Dualimaging&photothermaltherapyDensitygradientcentrifugationmethod:M.Hersam,Northwestern.ABCPolyethyleneglycol(PEG)SN-3802000000400000060000008000000400500600700Wavelength(nm)FluorescenceIntensitySN38GO-SN3800.20.40.60.811.2200400600800Wavelength(nm)AbsorbanceGOGO-SN38SN38,inmethanolGOLoadedSN38GrapheneforBiologyandMedicine•p-stackingofSN38cancerdruggrapheneoxidefordrugdelivery.•SN38:apotent,insolublecancerdrugJAm