生物传感器在医学中的应用现状和发展前景

402111¹2006.11,,(,441021)[],[];;[]TP212.3[]A[]1007-7510(2006)11-0040-05ThepresentsituationofapplicationsanddevelopmentprospectofthebiosensorinmedicalsciencesLOUHong,LIUJin,DENGGang(EquipmentDepartmentofXiangfanCenterHospital,XiangfanHubei441021,China)Abstract:Thebiosensorhasthegoodselectivity,thehighsensitivity,thequickspeedofanalysis,thelowcostandthecontinuousmonitoringon-lineinthecomplexsystem.Thisarticlesummarizedthebasicconcept,thebasicprinciple,thecharacteristic,theclassificationofthebiosensorandtheapplicationsinmedicalsciences,andcarriedontheforecasttoitsprospectsfordevelopment.Keywords:biosensor;medicalsciences;developmentprospect1,,,,,,()2060ClarkLyon(Biosensor),40,,,22.1(DNA),,:()(),,,2.2,1:(),,,,,,,,,,,2.3::2006-04-171412111¹2006.11DNA::33.1:,,,,3.1.1,,,,,,(2000)-DNA,,DNADNATPDDNA3.1.2,DNA,HBVDNA,,HBV,Antje(,)RNA,15RNA,,::70,80,,,,,LG,:,,,,,,,,30,:Cygnus,,,(),,,,ASLC(10502450)nmNIR,,,,,,FDA:(0.52)%,2422111¹2006.11,(23),,,,,,YSIBST,2003-3.1.3,,,,,2090,,(l2)20020,3.2,,,CMOSXCTXCTPET()3.2.1,,,,,DNA,DNA,DNA,,,DNA,,,,,(alterednanotube),,,3.2.2,,,,10,,,,:Alpha-MOSFOXCyra2nosciencesCyranoseCyranose32032,,Cyranose320,4,4,CMOS,,CMOS,,,3.2.3,,,,,,()DNA,913(),,,30,432111¹2006.11,,,,,,,,4,,,(),,,,,,:4.1,,,,4.2,,,,,,,,,,,,,4.3,,,,,,,,,,4.4MEMS()MEMS(MicroElectromechanicalSystem),MEMS,,,,,,MEMS,1959,MEMS4.5,,,,3:5,,:,:,,3442111¹2006.11,,,,,,(),,,[][1],,.[M].:,1997.[2].[M].:,1992.[3],.[M].:,1988.[4].[M].:,1984.[5],,,.[J].,2004,24(7):65-69.[6],.[J].,2002,8(1):72-75.[7],,,.[J].,2002,23(4):26-28.[8].[M].:,1998.[9]..,2004,3(5):1285-1287.[10]JagerEWH.MicrofabricatingConjugatedPolymerAc-tutors[J].Science,2000,290:1543.[11]YiCui.NanwireNansensorsforhighlysensitiveandselectivedetectionofbiologicalandchemicalspecies[J].Science,2001,293:1289.[12]RICKYK,SoongRK.PoweringanInorganicNandevicewithaBimolecularMotor[J].Science,2000,290:1555.[13]CaoLK,AndersonGP,LiglerFS.DetectionofYersiniapestisfraction1antigenwithafiberopticbiosensor[J].JClinMicrobiol1995,33(2):336.[14]JamesEA,SchmeltzerK,LiglerFS.Detectionofendotoxinusinganevanescentwavefiber-opticbiosensor[J].ApplBiochemBiotechnol,1996,60(3):189.[15]DevinePJ,AnisNA,WrightJ,etal.Afiber-opticcocainebiosensor[J].AnalBiochem,1995,227(1):216.[16]GrahamCR,LeslieD,SquirrellDJ.Geneprobeassaysonafibreopticevanescentwavebiosensor[J].BiosensBioelectron,1992,7(7):487.[17].[J].,2002,(10):33-35.4.2,,,4.3,;,,,,4.4,,,,;,,,,,,,,4.5,,,,,,4.6,,,:,,,,,,,,[][1].[M].,2004.[2],.[M].,2003.[3],.[J].,2005(5):25-28.[4],.1550[J].,2004(1):28-29.(39)