甲壳素和壳聚糖在生物矿化和模拟矿化过程中的调控作用研究进展

:(20471064);:(1982-),,,,*:Email:[e-mail].综述黄亚平1,赵莹2,过梅丽1,徐端夫2,王笃金2*(1北京航空航天大学材料科学与工程学院,北京100083;2中国科学院化学研究所工程塑料重点实验室,北京100080):95%5%,,():;;;()[1],[2~5],,[6~8](chitin),,(chitosan),1体内研究,[5,9][10~13],[13,14];[15],[8,16],[17],Mikkelsen[18],XRD,(034066),Careche[19],12,2体外研究,,,21Levi[15],,(1),,1(A,B)(C)(A);(B,C)(B)(C)[15]Figure1SEMmicrographsofchitin(A,B)andofchitinsilkassembly(C)aftercriticalpointdrying(A)Viewofthechitinsurfaceandedgeshowingthelamellarstructure;(B,C)Highmagnificationofthechitinsurfacebefore(B)andafter(C)depositionofsilk.[15]Falini[20]:,[21,22],-[23,24]NeiraCarrillo[25],,[26](CS)(PC)(CH),,(),CSPCCHCaCO3:PCCHCS,,,Manoli[27],,(2)22,Hirano[28]:;,1M[29],01M(pH220072=11),,,(3)2(A)(B)[27]Figure2Initialrateofcalciteformationonchitinsubstrateasafunctionoftheinitialcalciumionconcentrationinsolution(A),andasafunctionofthesolutionsupersaturationaccordingtotheclassicalnucleationtheory(B).[27]3(50m)1M[28]Figure3Timecoursefortheliberationofchlorideionsintodistilledwater()andintoaqueous1MK2CO3solution()fromonegranule(diameterca.50m)ofCaCl2chitosancompositematerials.Eachvalueistheaverageofthreeexperiments.[28]23[30]Falini[31];,Kato(4)[32][33][34],[33,35,36],[37],,,,32,Kato[32,37],,,,4[33][36]Figure4SEMmicrographsofthinfilm(A)[33]anddoublelayeredthinfilms(B)[36]ofcalciumcarbonategrownonachitosanmatrixZhang[22,38~41]X,,,(5),,Zhang[39](),5ApH45;BpH4563;CpH63[22]Figure1Schemeofexistingformsofpoly(acrylicacid)andchitosaninaqueoussolutionAlowpH45;BmediumpH45~63;ChighpH63.[22]6a;b;c;dAV,40m[42]Figure6SEMmicrographsofCaCO3islandcrystalsformedonchitosanmembranewithPAA:a,amixtureofaragoniteandvaterite;b,aragonite;c,vaterite;d,amixtureofaragoniteandvaterite.Smallparticlesareindicatedbyarrows.SymbolsAandVcorrespondtoaragonitecrystalandvateritecrystal,respectively.Scalebar,40m[42],Wada[42],,(6),;,,Wakayama[43]420072,Ichikawa[44]CO2HCO3-,(7)(pAsp)X,pAsp(15),25pAspKotachi[45]CO2+zinc-boundH2OHCO3-+H+(1)HCO3-+Ca2+CaCO3+H+(2)2HCO3-+Ca2+CaCO3+CO2+H2O(3)7[44]Figure7Equationsfortheformationofcalciumcarbonate[44]24,,Liang[46],XRDFTIRSEMCMCS,CMCS,CMCS(8),:[47]Kitano,(9),,8(CMCS)ah,CMCS0,10,100,500,1000,2000,5000,10000mgL,10m[46]Figure8SEMmicrographsofprecipitatedCaCO3fromCMCSsolutionswithdifferentconcentrationsCMCSconcentrationfrom(a)to(h):0,10,100,500,1000,2000,5000,and10000ppm.Scalebar,10m[46]3展望,[48~50]5291000mgL:a(),b(),c();:d(),e(),f()[47]Figure9InfluenceoftheincubationtimeonthemorphologyoftheCaCO3crystalsobtainedinthepresenceof1000ppmCMCSOneday:a(sideview),b(topview),c(bottomview);sixdays:d(sideview),e(topview),f(bottomview).[47],,(20471064)参考文献:[1],,,.,1988,10(3):246~254.[2]KrampitzG,GraserG.AngewChemIntEd,1988,27(9):1145~1156.[3]LowenstamHA,WeinerS.OnBiomineralization,NewYork:OxfordUniversityPress,1989,1~324.[4]MannS,WebbJ,WilliamsRJP.ChemicalandBiochemicalPerspectives,Weinheim:VCH,1989,95~131.[5],.,,:,2004,102~187.[6]AksayIA,TrauM,ManneS,etal.Science,1996,273(5277):892~898.[7]StuppSI,BraunPV.Science,1997,277(5330):1242~1248.[8]WeinerS,AddadiL.JMaterChem,1997,7(5):689~702.[9]WillisJ.AmZool,1999,39(3):600~609.[10]RoreR,DillamanR.AmZool,1984,24(4):893~909.[11]SimkissK,WilburKM.Biomineralization:CellBiologyandMineralDeposition,California:AcademicPress,1989,205~229.[12],.,1993,(6):37~40.[13],.,1997,13(3):206~209.[14]FlorkinM,StotzEH.ComprehensiveBiochemistry,NewYork:Elsevier,1971,595~631.[15]LeviY,AlbeckS,BrackAetal.ChemEurJ,1998,4(3):389~396.[16]LeviKalismanY,FaliniG,AddadiLetal.JStructBiol,2001,135(1):8~17.[17]WeinerS,TraubW.FEBSLett,1980,111(2):311316.[18]MikkelsenA,EngelsenSB,HansenHCBetal.JCrystGrowth,1997,177(1~2):125~134.[19]CarecheM,HerreroA,CarmonaP.JFoodSci,2002,67(8):2892~2895.[20]FaliniG,FermaniS,RipamontiA.JInorgBiochem,2002,91(3):475~480.[21]ZhangSK,GonsalvesKE.JApplPolymSci,1995,56(6):687~695.[22]ZhangSK,GonsalvesKE.Langmuir,1998,14(23):6761~6766.[23]HiranoS,InuiH,YamamotoK.EnergConversMgmt,1995,36(6~9):783~786.620072[24]HiranoS,YamamotoK,InuiHetal.MacromolSymp,1996,105:149~154.[25]NeiraCarrilloA,YazdaniPedramM,RetuertJetal.JColloidInterfSci,2005,286(1):134~141.[26],.,2001,17(2):202~208.[27]ManoliF,KoutsopoulosS,DalasE.JCrystGrowth,1997,182(1~2):116~124.[28]HiranoS,YamamotoK,InuiH.EnergConversManage,1997,38(Suppl.1):S517~S521.[29]HiranoS,YamamotoK,InuiHetal.StudSurfSciCatal,1998,114:621~624.[30]XuXR,HanJT,ChoKL.Langmuir,2005,21(11):4801~4804.[31]FaliniG,AlbeckS,WeinerSetal.Science,1996,271(5245):67~69.[32]KatoT,SuzukiT,AmamiyaTetal.SupramolSci,1998,5(3~4):411~415.[33]KatoT.AdvMater,2000,12(20):1543~1546.[34]KatoT,AmamiyaT.ChemLett,1999,28(3):199~200.[35]KatoT,SuzukiT,IrieT.ChemLett,2000,29(2):186~187.[36]SugawaraA,KatoT.ChemCommun,2000,(6):487~488.[37]HosodaN,KatoT.ChemMater,2001,13(2):688~693.[38]ZhangSK,GonsalvesKE.MaterResSocSympProc,1994,351:245~250.[39]ZhangSK,GonsalvesKE.MaterSciEngC,1995,3(2):117~124.[40]GonsalvesKE,ZhangSK.PolymMaterSciEng,1995,73:302~303.[41]ZhangSK,GonsalvesKE.JApplPolymSci,1995,56(6):687~695.[42]WadaN,SudaS,KanamuraK,etal.JColloidInterfSci,2004,279(1):167~174.[43]WakayamaH,H