帕金森病的药物治疗方案

PD3,:311,,50100mg,23,26mg,23;,,,l2,,,50100mg,2(olanzapine)PD,,80%,,[JNeuropsychiatryClinNeurosci,1999,11(3):392-394],,24mg,2,2,2155.0mg,2,510mg,2,,8.012.0mg,,,,312,,,,50200mg/d,23,,,5-(SSRI),()(),20mg/d,1,50mg/d,1,,,,,PD,,313,314,315,,,2515mg0.40.8mg,,(,deanxit)5-(SSRI),:(1930-),,,,:2000-06-20(:)(,221002):R74215:A:1002-0764(2000)12-0005-03(PD),PD4,3PD,,,1111PD,65,65PD1121,2252000122312113,,,114,,115,,2PD211(amantadine)(DA),DA,(EAA),NMDAMetman,PD[Neurology,1998,50(5):1323-1326],,50100mg,3,,60%80%212(Ach),DAAch,(artane)220mg/d(akineton)2120mg/d3PD311(LD)LD(DDC)DA,,LD,,,(madopar,LD0.10.2g2550mg)(sinemet,LD0.2g50mg),10.51/d,10.51/d,48/dDDCLD,312LD3121131212,,-()LD31213,PD31214LD(longtermL-DOPAsyndrome)35a(1)(dyskinesia)LD,DADA,DA()(),,(tiapride)(2)(enddosedeterioration),,DA(akinesia),,,(up-down)(3)(on-off),,DA12,DAPD,(sinemetconfrolledrelease),018g(madopar-hydrodynamicallybalancedsystem),(1999)5/12(4)(freezingepisodes)(earlymorningoff),,,1LD,(drugholiday),(,1997),LD710d,,LD50%,30%4(DARA),LD,411DA(domporidone)412(1)(bromocriptine):D2,DA,1.02.5mg/d,1020mg/d,,LD10a;(2)(pergolide):D1D2,10,4:150300g/d,6JournalofPostgraduatesofMedicine,December2000,Vol.23,No.12AlbertoAlbanese65DARA,DA413(piribedil,):DA,D2D3PagliariDA,42%,31%,32%(JNeurolTransm,1995,101:13-26),PD,DA,Rondot(1992)50mgPD0.100.15g30%50%(1999)50PD,0.100.15g/d,62%414ropinirolepramipexole5(MAO-B)DAMAOCOMT,(HVA),MAO(selegilie),,,+E(DATATOP)LD,LD(2000)LDPDLD1017%,80%50%,,LeesPD,(BrMedJ,1995,311:1602-1607)6--(COMT)COMTDA,DA,COMTDA3-(3-OMD),,COMT,(tolcapone)(entacapone),3-OMD90%,LD(ADC)2,23-OMD60%,LD(ADC)30%0.10.2g/,137Ach,DA(desferal)DAEAA(lamotrizine),PDVCVESOD-,BQ10,PD,DARACOMT+L-DOPA/DDCIL-DOPA/DDCIDATATOPLDPD:(1932-),,,,,:2000-06-20(:),(,100000):R74215:A:1002-0764(2000)12-0007-03(Parkinsondisease,PD),,,,(STN)(Gpi),72000122312