第六章解热镇痛药和非甾体抗炎药

12ƒƒ34ƒ–ƒ––5ƒ–ƒ6ƒ–7ƒƒ–ƒ––8910ƒƒ––z–11ƒƒƒ––HOOOONHOHO1213ƒƒHOOOO14ƒƒHOOOO215ƒƒ16ƒHOOOH17ƒƒONaOHONaOCO26atm,125-140oC18ƒƒƒ19ƒƒ20OOHOH+OOOOOHOOH2SO470~7521ƒƒƒ–OOHOH22ƒ––OOHOOOOO+OOOOOOO23ƒOOO++OOO+OHOHOOOOOOHOOOHOOOO24ƒƒƒHOOOO25ƒƒ–––zOOHOH26OHOHOOHOOHOOOHO+OHOOOOO[O]OHOOHOHOOHOOHOOHOHOHOOHOOO[O]27ƒƒOOOHFe/3+Fe3+OOHOH28ƒƒ–OOHOONa2CO3/H2OheatOOOHNaH2SO4OOHOH+OHO29ƒ–ONHOHOHOSalicylglycineOOHOGlucOOGlucOHGlucuronideGlucuronide30SalicylicacidAcetylsalicylicacidONHOHOHOOOHOHOOHOOGlycinOOHOGlucOOGlucOHOOHOHHOSalicylglycineGlucuronideGlucuronide31ƒƒHOOOO32ƒƒ–33ƒƒƒHOOOO34ƒƒ––HOOOO35OOOO2·AlOH2+OOOOH3NNH3OOOOOONOHOOOO2·2Ca2·H2NONH236HOOOOSalicylicAcid3738ƒƒNHOHO39ƒƒNHOHO40ƒ––z–NHO41ƒƒ––NHOO42ƒƒNHOO43ƒƒ–ƒNHOHO44ƒƒNHOHONHOO45NO2HONH2HONHHOOFe,HClAcOH46ƒ–OHFe(CN)5H2NNa247ƒƒƒNHOHO48ƒƒ49ƒNHOHO50ƒ-NHOO.+++3Fe51ƒ–βHONN+NNHO52,HONOOHNHOHONHOONH2ONHONHOGlyOOONHOOSHO53N-GSHN-HONOOHNOHOONONOHOSNHOOHONOHOSG54ƒƒƒNHOHOHOOOO5556ƒ–NHOHOHOOOOƒƒ57ƒ