水凝胶在医学领域的热点研究及应用

3(06KJ161);(04XSYK227):,1968,,,Tel:[phone]E2mail:[e-mail]3,(,710721)Hot2spotResearchandApplicationofHydrogelinBiomedicineFieldYANGLianli,LIANGGuozheng(CollegeofScience,NorthwesternPolytechnicalUniversity,Xian710721)AbstractHydrogelsaremoderatecrosslinkedandbranchedpolymers.Theyarewidelystudiedandappliedintheworld,becausetheyhavetheabilitytoabsorblargequantitiesofwater,swellquickly,anditissoftandofelastineviscosityandbiologicconsistence.Inthispaper,studyhotspotsofhydrogelinbiomedicinefieldarereviewed.There2searchprogressintheapplicationareprospected.Keywordshydrogel,medicine,hotspot,application,,,,,,,,,,,,,[14],11.1pH[58][9]5N2(PNIPA),,PNIPA,Shah[10],/Fe3O4,(st)N2(NIPAM),Fe3O4/P(st2NIPAM),,1.2,2060Wichter2leLim2(HEMA),Nagarsekar[11](SELP),Cappello[12]SELPSanDiegoSELPKobayashi[13]90%17500(PVA2H),,Malmonge[14]PVA2H,,,Oka[15]1ISO1099321:1992GB/T16886.121997,,1948RosenBluth,21120072212PVP2g2NIPAAmL929,,[10,1618]1.3:;,,,[13,19]Iwakura[20],,(BIO2BIS),N,N2,PVPP/PVA,,1.4[21,22][23]/,,80%,NagarsekarA[11]k,412,,,1.51998,,,,,,2AssadangPolnokAc2Di2Sol,,,,F.A.Dorkoosh[24],Tc299m5,75150min,4560min,,,MrciaR.deMoura[25],,,22.1,(DDS)DDS33,,,,Miya2ta[26]2,rabbitIgG,,,Hs2lihe[27]PolyNIPAMPolyNIPAM,,8Zhai[28]PVANI2PA(PVA2g2NIPA),PVA,2PVA2g2NIPA/PVAMB48PVA2g2NIPA/PVA15,PVA2g2NIPA/PVA,482.2,,[29]NVP2HEMA,1,,[30]N2(NVP)2(HEMA)C()(KH570),N,N2(NMBA),(AIBN),,1151,99%,2.3,:,;,;,;,;,,;,;,[31,32]311/,HajekM[33]Sorbalgon,,,,,GoodheadA[34]Comfeel,,,,,,,,2.4,N2N2,,,,,,,[16,17]2.5,N2Femandez[35]22222,,,,2Burns[36]p(NIPAAm)P,,/,,Zhao[37],p(NIPAAm)/AAc,2.6,,,,,,,BurnsJ.W[38],Seprafilm,7,28,51%,,6%,,,PIP,,4,,,2.7,,,DNALangzaRP[39],,,,1500,,,200,,,3,,,,,,,,,,,,,,,,1,..:,2005.12..:,2002.4733,,,..:,2005.14WichterleO,LimD.Hydrophilicgelsinbiologicuse.Na2ture,1960,185:1175,,,..,1998,5:6286KwonIC,BzeYH,OkanoT,etal.Drufromelectriccur2rentsensitivepolymers.Rel,1991,17(2):149411200722127,,,..pH.,1997,1:1068,.pH()/(N2).,1998,1:399,,,.N2.,1995,3:32110ShahSS,KulkamiMC,MashelkarRA,etal.pHdependentzeroorderreleasefromglassyhydrogels:penctrationvs.dif2fusioncontrol.JContrRel,1991,15(2):12111NagarsekarA,CrissmanJ,CrissmanM,etal.In:AAPSWorkshoponCriticalIssuesintheDesignandApplicationsofPolymericBiomaterialsinDrugDelivery,Arlington,VA,200212CappelloJ,DombAJ,KostJ,etal.Handbookofbiodegradablepolymers.Amsterdam:HarwoodAcademicPub2lishers,1997.38713KouJH,AmidonGL,LeePI.pH2dependentswellingandsolutediffusioncharacteristicsofpoly(hydroxy.ethyl.meth2acrylate2co2methacrylic,acid)hydrogel.PhamRes,1988,5(9):59214KimCJ,LeePJ.Hydrophobicanionicgelbeadsoswellingcontrolleddrugdelivery.PharmRes,1992,9(2):19515KwonIC,BzeYH,KimSW,etal.E2erodiblepolymergelforcontrolledrelease.Nature,1991,354(28):29116,,,..,2001,1:5417,,,..,1999,20(11):96618Iwakura,Taiichiro.CataplasmscontainingD2polyglutamicacid.JPPat,20000014691.200020121819..:,2002.41320Sukegawa,Makoto,etal.Manufactureofpoly(aminoacid)partwithnarrowparticlesizedistributionandtheirusesaswatersorbents.JPPat,11240958.199920920721LiangL,LiuJ,GongXY.Thermosensitivepoly(N2isoprop2ylamide)2claynonocompositeswithenhancedtemperatureresponse.Langmuir,2000,16:989522,,.N,N2/.,2003,3:32623,,,./.,2005,5:59924HosseinOmidian,JoseG,etal.Advancesinsuperporoushy2drogels.JContrRel,2005,102(1):325MrciaRdeMoura,MarcosRGuilherme,GilsineiMCampese.Porousalginate2Ca2+hydrogelsinterpenetratedwithPNIPAAmnetworks:Interrelationshipbetweencom2pressivestressandporemorphology.EurPolymerJ,2005,41(12):284526SchmedlenRH,MastersKS,WestJL.Photocrosslindablepolyvinylalcoholjydrogelsthatcanbemodifiedwithcelladhisionpeptidesforuseintissueengineering.Biomaterials,2002,23:432527BurgessB.Aninvestigationofhydrocolloid.Acomparativeprospectiverandomizedtrialoftheperformanceofthree2hydrocolloiddressings.ProfNurse,1993,8(suppl7):328ZhaiML,LiuN,LiJ,etal.RadiationpreparationofPVA2g2NIPAAminahomogeneoussystemanditsapplicationincontrolledrelease.RadiationPhysChem,2000,57:48129,.NVP2HEMA.,2004,24(2):2730,,,..,2005,24(4):39931,..,2003,28(5):47032,,..,2001,5:26833HajekM,SedlarikKM.Advantagesofalginatebandagesforcoverageofextensiveandpoorlyhealingwounds.RozhiChir,1992,71(324):15234GoodheadA.Clinicalefficacyofcomfeelplustransparentdressing.BrJNurs,2002,11(4):28435FemandezDegiorgiC,PizarroRA,SmolkoEE,etal.Hy2drogelsforimmobilizationofbacteriausedinthetreatmentofmital2contaminatedwastes.RadiationPhysChem,2002,63:10936KweonHY,YooMK,ParkIK.Anoveldegradablepoly2caprolactonenetworksfortissueengineering.Biomaterials,2003,24:80137ZhaoJianqing,CaiLiangzhen.Preparationofhydrogelforintelligentwindow.ChinaSyntheticRubberIndustry,2000,23(5):32538BurnsJW.BacteriaDerivedSodiumHyaluronateBasedProductsforPostSurgicalAdhisionPrevention.211thACSNationalMeeting.NewOrleans:LA,March24/281996,Abstracts,BTEC00439NikhilJ.Noveldeliverysystembasedoncomplexationhy2drogelsasdeliveryvehiclesforinsulin2transferrinconju2gates.Biomaterials,2006,27:3846()511/