蒲公英药理作用研究进展-于立恒

236004R285．5B1004－2814201205－617－04。HerbaTaraxaci、、、、、。《》2010Ta-raxacummongolicumHand．Mazz．、Tarax-acumsinicumKitag．。200070。、。、、、、、、、、、、、、、、、、、、、。、、、、、、、、、、、、、、、、。、、、、、、、、、、、。。1、、、、、。1203MIC。、。HeW2A/PR/8/34WSNH1N1。PCR0．625～5mgmLMadin－DarbyMDCKA549PR8WSNNPRNA。3、、。0．43g/L。41∶4、、、、、、、、。5、DNA。6、、、、。2。Schutz7100mg/kg。Yoon－JeoungKoh870%RAW264．7iNOSCOX－2。9100、、、。、、。10LPSALILPSALI、、·716·287234JOURNALOFPRACTICALTRADITIONALCHINESEMEDICINE2012Vol．28No．7syzyyzz.com2．5、5．0、10．0mg/kg0．5mg/kgSODINF2γ、NO、PGE2LPSALISODBALFINF2γ、NO、PGE2ALI。3Hagy-masi11－12Wistar。NADPHADP－Fe2+。CNADPH。Hagymasi、。、。JozefHudec13O－。ChungMuPark14SD。ChungMuPark15RAW264．7NF－γBiNOS。16Fen-tonti·OH。17β－O2－、·OHPOVAV。4。18AGS、AGSG2/M。19、Lovo。。OvadjeaP20－8－3。FADD。。5DomitroviR21DWEDWE、α－SMAGFAPDWE。22ALT、AST、、ALT、ASTALTAST。2337℃10mLkrebsBL－420。m、β、a、H。624、。25。26。727P＜0．01。28DPPHFRAPα－。14SOD、MDAGSH－Px。α－。·816·20127287234JOURNALOFPRACTICALTRADITIONALCHINESEMEDICINE2012Vol．28No．78You29。25TGHDL2CTGLDL－C。3024。Neef31。ADP。0．04g/mLPRP85%。Mr＞10000Mr＜100000．04g/mLPRP91%80%。932。33。。10341g/kg·g21、、、。。、。11LubnaHT35。36。100BALB/c、、、、、2550100mg/kg。CVB3137914TUNEL－8caspase－8。。37。。38。3916。WarashinaT40。ClareBA41171P＜0．052P＜0．01。12。。1．J．20099112542－2543．2HeWHanHWangWetal．Anti－influenzaviruseffectofaqueousextractsfromdandelionJ．VirolJ201183538－542．3．J．200735843－45．4．J．195754286－286．5．J．2010403307－311．6．J．201021474453－4455．7SchutzKCarleKSchieberA．Taraxacum－AreviewonitsphytochemicalandpharmacologicalprofileJ．JEthnophar-macol20061073313－323．8Yoon－JeoungKohDong－SooChaJe－SangKoetal．Anti－In－flammatoryEffectofTaraxacumofficinaleLeaveson·916·20127287234JOURNALOFPRACTICALTRADITIONALCHINESEMEDICINE2012Vol．28No．7Lipopolysaccharide－InducedInflammatoryResponsesinRAW264．7CellsJ．JMedFood2010134870－878．9．50J．2010218135－136．10．SODJ．2010381790079056．11HagymasiKBlazovicsAFeherJetal．TheinvitroeffectofdandelionantioxidantsonmicrosomallipidperoxidationJ．PhytotherRes200014143－44．12HagymasiKBlazovicsALugasiAetal．Invitroantioxi-dantevaluationofdandelionTaraxacumofficinaleWEB．waterextractsJ．ActaAlimentaria20002951－7．13〗JozefHudecMáriaBurdováLu＇bomírKobidaetal．An-tioxidantCapacityChangesandPhenolicProfileofEchina-ceapurpureaNettleUrticadioicaL．andDandelionTa-raxacumofficinaleafterApplicationofPolyamineandPhe-nolicBiosynthesisRegulatorsJ．JAgricFoodChem200755145689－5696．14ChungMuParkHyunJooYounHeeKyungChangetal．TOP1and2polysaccharidesfromTaraxacumofficinaleat-tenuateCCl4－inducedhepaticdamagethroughthemodula-tionofNF－κBanditsregulatorymediatorsJ．FoodChemToxicol20104851255－1261．15ChungMuParkJiYoungParkKyungHeeNohetal．Ta-raxacumofficinaleWeberextractsinhibitLPS－inducedoxi-dativestressandnitricoxideproductionviatheNF－κBmodulationinRAW264．7cellsJ．JEthnopharmacol20111332834－842．16．J．2009373101－103．17．J．201033381－84．18．AGSJ．201196638－642．19．5J．2005274300．20OvadjeaPChatterjeeaSGriffinCetal．Selectiveinductionofapoptosisthroughactivationofcaspase－8inhumanleu-kemiacellsJurkatbydandelionrootextractJ．JEthno-pharmacol2011133186－91．21DomitroviRJakovacHRomiZetal．Antifibroticactivi-tyofTaraxacumofficinalerootincarbontetrachloride－in-ducedliverdamageinmiceJ．JEthnopharmacol20101303569－577．22．J．20111711179－181．23．J．2010173213－214．24．58J．2009141228．25．J．2009232143－145．26．J．20081226818．27．J．201033636－37．28．J．200920272095－2097．29YouCLMikioN．Effectsoftaraxacum－extractontheisola-tedrataortaJ．NiigataIgakkaZasshi199210612513－514．30．24J．2000324287－288．31NeefHCilliFDeclerckPJetal．PlateletantiaggregatingactivityofTaraxacumofficinaleWeberJ．PhytotherRes1996104S138－S140．32．J．200829411－13．33．J．200829410－12．34．J．2011393320402－20403．35LubnaHTNoorMAMariamYAetal．DandelionTaraxa-cumofficinaledecreasesmaleratfertilityinvivoJ．JEth-nopharmacol20111351102－109．36．J．20111710215－218．37．J．2009312119－122．38．J．2007252134－136．39．J．20008315．40WarashinaTUmeharaKMiyaseT．ConstituentsfromtheRootsofTaraxacumplatcarpumandTheirEffectonProlifer-ationofhumanSkinFibroblastsJ．ChemPharmBullTo-kyo2012602205－212．41ClareBAConroyRSSpelmanK．Thediureticeffectinhu-mansubjectsofanextractofTaraxacumofficinalefoliumo-verasingledayJ．JAlternComplementMed2009158929－934．2012－03－14·026·20127287234JOURNALOFPRACTICALTRADITIONALCHINESEMEDICINE2012Vol．28No．7syzyyzz.com