2015年美国CDC生殖器疱疹治疗指南解读

[e-mail]530CHINJDEＲMVENEＲEOL20165305May2016Vol．30No．5··2015CDCHSV。、、HSV-1、、HSV、HSVHIVHSV201565Workowski。Ｒ752.1B1001－7089201605－0530－04DOI10.13735/j.cjdv.1001-7089.201509071Interpretationof2015UnitedStatesCDCGenitalHerpesTreatmentGuidelineKEWu-jianYANGBinClinicＲesearchCenterGuangdongProvincialDermatologyHospit[e-mail]dbysomeissuessuchasatypicalclinicalmanifestationsasymptomaticviralsheddingdifficultinterpretationofHSV-1antibodiesposi-tivedistinguishingepisodicandsuppressivetherapythepreventionandtreatmentofHSVinpregnancyhowtoavoidneonatalHSVinfectionandco-infectionwithhumanimmunodeficiencyvirusHIV.ThereforeonJune52015Dr.Workowskileddozensoftopprofessorsspecializedinthefieldofsexuallytransmitteddisea-sesintheCentersforDiseaseControlofUnitedStatestoissuethelatestSTDtreatmentguideline.KeywordsGenitalherpesDiagnosisTreatmentUSguideline、。HSVHSV-1HSV-2。HSV-25000HSV-2。HSV-1。HSV-2。。HSV。。1。HSV-2HSV-1。HSV-1HSV-2HSV。STDHSV。HIV。1.1HSVPCＲ。。PCＲHSVDNA。PCＲHSV、。PCＲHSV。HSVPCＲHSV。HSVTzanck。IFHSV。1.2HSVHSVHSV。HSVG2G1HSVHSV-1HSV-2。GglycoproteingGHSV。HSV-2。HSV-280%～98%。HerpeSelectHSV-21.1～3.5。Biokit。HerpeSelectHSV-2HerpeSelectHSV-2HSV-2。。HerpeSelectHSV-1HSV-1。HSV-1HSV-2IgM。HSV-2HSV-2HSV。HSV。HSV-1①HSV-1HSV②HSV-1HSV-1。HSV-1HSV。HSV-2HSV①HSVPCＲ②③。HSVHIVHIV。HSV-1HSV-2。2。、、。。、、。、、。。。。2.1。。。400mg3/d7～10d200mg5/d7～10d1g2/d7～10d250mg3/d7～10d10d。2.2HSV-2HSV-2HSV-1。HSV-2。/。。HSV-2HSV。2.370%～80%。。6、1。。。11。1HSV1500mgHSV-2。。MSMHSV-2。、、。。400mg2/d500mg1/d≥10500mg1/d1g1/d400mg2/d1g1/d250mg2/d。2.41d。。400mg3/d5d800mg2/d5d800mg3/d2d500mg2/d3d1g1/d5d125mg2/d5d1g2/d1d500mg1250mg2/d2d。2.5HSVHSV、。8h5～10mg/kg2～7d10d。HSV21d。。·135·20165305ChinJDermVenereolMay.2016Vol.30No.53。、。。http//、。HSV-2HSV。、、、。HSV-2HSV。HSV-2HSV-2。。、、。。HSV①、、、②③④⑤HSVHSV-2HSV-1HSV-212⑥HSV⑦HSV-2HIVHSVHSV-2⑧⑨HSVHSV⑩HSV瑏瑡HSV-2HIVHSV-2HIV。4。。HSV。55.1、、、。。5.2HIV、。HIVHSV、、。HIVHSV。HSV。。HIVHSV。HSVHIVHSV。HSV-2。HIVHSVHIVHSV-2。HSV5～10mg/kg8h1。HIV400～800mg2～3/d500mg2/d500mg2/d。HIV400mg3/d5～10d1g2/d5～10d500mg2/d5～10d。5.3HSVHSV。。。8h40～80mg/kg。15mg/kg。1%。15d。HIV。。6。HSVHSV30%～50%HSVHSV＜1%。HSV。HSV。。-。HSV。HSV。HSVHSV。HSV-2。。。。HSVHSV。·235·20165305ChinJDermVenereolMay.2016Vol.30No.5。。。HSV。。HSV。HSV。400mg3/d500mg2/d36。7HSV。HSVPCＲ。HSV。。20mg/kg8h114d21d。82015CDC20101aHSV-1bHSV-2HSV。2aGglycoproteingGHSVbHSVcPCＲHSVHSVdHSV-1HSV-2IgMeIF。3abcHSV21ddHSVHSVef。4abHIVHSVHIVHSV-2cHSVHSV。11WorkowskiKABolanGACentersforDiseaseControlandPrevention．Sexuallytransmitteddiseasestreatmentguidelines2015J．MMWＲＲecommＲep201564ＲＲ－0327－32．2015-09-152015-11-25、2016－04－12－031、I8201663—6。、、、、、、。http//sypft．cnmanu．cn/[e-mail]·335·20165305ChinJDermVenereolMay.2016Vol.30No.5