Olivem-1000中文资料

Olivem®1000–CrystalSkin™®Olivem®1000–CrystalSkin™SlideNumber2SIntroduction简介SOlivem®1000–CrystalSkin™SLiquidCrystalsandtheMechanismsofAction液晶结构及机理SClinicalStudies-Olivem®1000–CrystalSkin™临床测试SBiologicalStudies皮肤生物功效的研究SProductApplication应用SConclusion结论Contents概要Olivem®1000–CrystalSkin™SlideNumber3BarrierProtectionfromForeignParticles皮肤屏障Environment&Pollution环境和污染UVDamageVersesUVBenefits阳光的益处与损伤MoistureRetention保湿锁水ImmuneDefense免疫Olivem®1000–CrystalSkin™SlideNumber4Thebeautyandanti-agingplatformisabalancebetweenprotectionversusmoistureretentionversusskinfunction.“美丽与延缓衰老”来自防护、锁水保湿与皮肤功能间的平衡Olivem®1000–CrystalSkin™SlideNumber5Olivem®1000–CrystalSkin™LiquidCrystalGenerator形成液晶结构AnActiveIngredientwithFunctionalActivity具有乳化功能的活性成分®Olivem®1000–CrystalSkin™SlideNumber6SAnti-aging抗衰老SAnti-oxidant/inflammatory抗氧化/抗炎SSkinlighteningagent亮肤SAnti-acne抗痘SHairgrowth头发再生SLipolytic脂解Activeingredientsareconsideredtohaveapharmacologicalalteringeffectonskin,andtheseeffectsmustbedocumentedbyscientificevaluationwhichcanbereplicated…活性成分是指对皮肤有药理学方面改善的效果，并得到科学验证评估，同时功效可以再现SBiomimeticrestructuringagent仿生皮肤再建Olivem®1000–CrystalSkin™SlideNumber7SBiomimeticrestructuringagent(Biomimicoftheskinlamellarbilayerlipids)仿生皮肤再建成分（仿生人体皮肤角质层细胞间脂质）SChemicalcompatibilitywiththeskinsurfacelipidcomposition与皮肤表层皮脂化学组成相似SGeneratesstableskin-compatibleliquidcrystals形成亲夫稳定的液晶结构SEffectiveconcentration2-5%建议添加量2-5%;SEmulsifiesinwateraswellasinoil水、油中皆可乳化SMeltingpoint65-75°C熔点65-75°CSCompatiblewithelectrolytes,DHA,AHA,pH3.0-12.0与电解质、DHA、AHA配伍，pH值3.0-12.0SContainsnopreservative;PEG-free不含防腐剂；不含环氧乙烷SShelf-life:5years保质期五年SNaturalOrignasconfirmedby天然来源得到ECO-CERT认证Olivem®1000–CrystalSkin™INCIName“CetearylOlivate,SorbitanOlivate”鲸蜡硬脂基橄榄油酯,山梨醇橄榄油酯ECOCERTOlivem®1000–CrystalSkin™SlideNumber8Coconutoil椰油Oliveoil橄榄油HumanSkinUnsaponifiables不可皂化物max0.61.0-1.55.0Palmitic棕榈酸8.0-107.5-2025-29Stearic硬脂酸1.5-5.00.5-5.020-28Oleic油酸6.0-9.055-8330-35Linoleic亚油酸1.0-2.23.5-13.53.0-3.5Linolenic亚麻酸max0.3max0.8max1.2Lauric月桂酸42-52──Myristic肉豆蔻酸16-190.1─Capric癸酸6.0-8.0──Caprilic辛酸5.0-10──Capronic己酸0.5-10──OliveOiliscompatiblewithHumanSkin橄榄油与人体皮肤对比EssentialfattyacidsPotentialskinincompatibilityOlivem®1000–CrystalSkin™SlideNumber9CompositionofOliveOil橄榄油成分•Linoleicacid亚油酸(C18:2,omega-6)•Linolenicacid亚麻酸(C18:3,omega-3)Fattyacids脂肪酸•Oleicacid油酸(C18:1)Olivem®1000–CrystalSkin™LipophilicHydrophilicOlivem®1000–CrystalSkin™SlideNumber10LIQUIDCRYSTALSANDTHEMECHANISMOFACTION液晶结构及其作用机理®Olivem®1000–CrystalSkin™SlideNumber11TheLiquidCrystals液晶SLiquidcrystalsformedbyOlivem®1000–CS™产品形成的液晶Sunderpolarizedlight-microscopy偏振光显微镜下观察Olivem®1000–CrystalSkin™SlideNumber12Olivem®1000–CS™HLLateraljuxtapositionofOlivem®1000-CSactivatedbyintermolecularforces在分子间作用力下的OLIVEM1000-CS的层状液晶Formationofbilayerlipidlamellae形成双层状油脂结构ÆMultilamellarsystem多层体系SGenerationofliquidcrystalstructures形成液晶结构SSpatialorganisation+Fluidity空间的结构+可流动性Howtheliquidcrystalsareformed?液晶是如何形成的？TheLiquidCrystalsOlivem®1000–CrystalSkin™SlideNumber13Mechanismsofaction作用机理SSkinlamellarlipidmatrix皮肤层状油脂架构SLiquidcrystallamellaeofthestratumcorneum角质层的液晶层SSkinbarrierfunction皮肤屏障功能SContributionofsebum-derivedfattyacidsandlamellarlipids皮肤分泌的脂肪酸及层状油脂的作用SPhysiologicalactionofOlivem®1000–CS生理学功效SBiomimetism仿生性SMaintenanceofskinbarrierhomeostasis维系皮肤屏障动态平衡Olivem®1000–CrystalSkin™SlideNumber14SSkinlamellarlipidmatrix皮肤层状油脂架构SLiquidcrystallamellaeofthestratumcorneum角质层的液晶层SSkinbarrierfunctionSContributionofsebum-derivedfattyacidsandlamellarlipidsSPhysiologicalactionofOlivem®1000-CSSBiomimetismSMaintenanceofskinbarrierhomeostasisMechanismsofaction作用机理Olivem®1000–CrystalSkin™SlideNumber15¶¶ModifiedfromJInvestDermatol120:275-284,2003keratinocytekeratinocytecrystallinephaseliquidphasecrystallinephaseH2OH2OH2OH2OH2OH2OH2OH2OH2OH2OstratumcorneumstratumgranulosumskinsurfacebilayerlipidlamellaebilayerlipidlamellaeKeratinocytesandtheintercellularlipidlamellaehaveprimordialrolesintheskinbarrierfunctionÆLipidsofthebilayerlamellaecanbeorganizedinliquid-crystalstructuresÆBarrierfunction•keratinocytes•intercellularlipidlamellaeBarrierfunction•keratinocytes•intercellularlipidlamellae10nmLipophilicpathwayLamellarbodiesaresynthesizedinthestratumgranulosumandbecomeorganizedintothestratumcorneumasbilayerlipidlamellaebetweenkeratinocytesLamellarbodiesBilayerlipidlamellaeOlivem®1000–CrystalSkin™SlideNumber16SSkinlamellarlipidmatrixSLiquidcrystallamellaeofthestratumcorneumSSkinbarrierfunction皮肤屏障功能SContributionofsebum-derivedfattyacidsandlamellarlipids皮肤分泌的脂肪酸及层状油脂的作用SPhysiologicalactionofOlivem®1000-CSSBiomimetismSMaintenanceofskinbarrierhomeostasisMechanismsofactionOlivem®1000–CrystalSkin™SlideNumber17DesquamationdisturbstheintegrityofthelamellarlipidbarrierintegrityformingmicroporesthroughwhichwatercanescapeÆOrganized«gel»phase规则排列Disorderedphase不规则WhatisDesquamationNaturalprocessofcellturnover;howevertheprocesscanbeaccelerated!!!!Inflammatione.g.UVinducedOxidisation/Pollution/FreeRadicalsAggressivewashing;e.g.skinincompatibilityagents,chemicaldepositionEffectsofchemica