尘螨变应原诊断和免疫治疗哮喘与鼻炎安全性分析3

312112112000322:(Dermatophagoidesfarinae):19741995(SMU2Df):846342142,11689(CL=11492109);018290177901079(CL=114ö1210ö)0102930min32,1h2h6;3h48h88,18,96,146,41,:22SMU2Df,,,80%IgE[1]70,(Der2matophagoidesfarinae),(SMU2Df),SMU2Df[2,3]SMU2Df7615%[4,5],82%[6];78%,8817%[710]26,200,3(No.39270638),SMU2Df,(),:(19741995),(11),,,,,,,,145,86,2,84634221974,199522,,1980()197919801680,,1995112282,15683SMU2Df846342142,11689,Poisson(CL)118.6165.411492109,696562,01829017790107901029(7ö,CL=114ö12.0ö),,4816%,,4518%,,018290177944721999;17(5)274276ChineseJournalofParasitologyandParasiticDiseases©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(1)30min,13h48h518,96,14,14(2)963,3%1SMU-Df(142)2SMU-Df(142)Fig.1TimeofonsetofsystemicadversereactionsassociatedwithskintestsandsubcutaneousinjectionsofSMU-Dfmiteextract(142cases-times)Fig.2Timeofonsetofsystemicadversereac-tionoccurredphasesassociatedwithskintestsandsubcutaneousin-jectionsSMU-Dfextract(142cases-times)666,41(62%),18(27%),7(11%)782,O221114244,,,841:2214(15000wöv1ml)311,[5,6]198693:;;2h,,2h,,75%,[13],,,6ö,7ö[14],,,,,,,:(30min):,IgE,,;,,B2,;,;,,,,,(3h48h):,B2,,,,,,572©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[15],,,1,18,T,,3,,,,[15],[15],,(preventiveallergytreat2ment,PAT):,,1,,,.IgE.1985;529332HaymannPW,ChapmanMD,AlberseRC,etal.AntigenicandstructuralanalysisofgroupIIallergens(DerfIIandDerpII)fromhousedustmites(Dermatophagoidesspp).JAllergyClinImmunol1989;83105510673WenT,WangE,ShenS,etal.AllergenicpotencyofSMU2DfextractincomparisonwithVUS2Dfextract;anddiagnosisandimmunotherapyforatopicdermatitisandrhinitiswithSMU2DfextractinChina.ArbPaul2Ehrlich2Institut1991;852172274ChuJ,WenT,ChenX.Treatmentofasthmicpatientssensi2tivetomites(Dermatophagoidesfarinae).AnnAllergy1981;461071095,,,..1985;82072106.50.1995;23(9)37387,..1990;102222238,,,..1993;132962989,..1978;(11)363810,,,..II..1987;1611812011CommitteeontheSaftyofMedicinesCSMupdate:Desensitisingvaccines.BrMedJ1986;29394812RowlinsMD,WoodSM,MannRD.Harzardswithdesensiti2zingvaccines.ArbPaul2Ehrlich2Institut1988;8214715113FranklandAW.DesensitisinginjectionsintheUnitedKing2dom.ArbPaul2Ehrlich2Institut1988;8220921114DAmbrosoFP,RicciardiL,IsolaS,etal.Severeadversere2actionsduringspecificsubcutaneousimmunotherapy.Allergy1996;516215BousquetJ,LockeyRF,MallingHJ,etal.WHOpositionpa2per2Allergenimmunotherapy:Therapeuticvaccinesforallergicdiseases.Allergy1998;44(Suppl.53)14219997201999930(:)SAFETYANALYSISOFDUSTMITEALLERGENFORDIAGNOSISANDIMMUNOTHERAPYOFASTHMAANDRHINITIS3WENTinghuan1,CAIYingyun2,CHENXiujuan1,XIANGLi1,WANGBeiling2,ZHUANGYijun11MedicalAcarologyLaboratory,2DepartmentofPulmonology,ShanghaiMedicalUniversity,Shanghai200032ABSTRACTAIM:TomakearetrievalinvestigationofsafetyinusingDermatophagoidesfarinaeextractindiagno2sisandimmunotherapywithpatientsofasthmaandrhinitis.METHODS:AquestionnaireevaluationofthesafetyuseofD1farinaeextract(SMU2Df)duringdiagnosisandimmunotherapyofpatientsfrom1974to1995wascarriedout.RESULTS:Atotalof846342injectionswerestatisticallyanalysed,amongwhom142systemicadversereactionsoccurredinvolvingurticaria0.829,severeattackofasthma01779,ana2phylacticshock01079(CL=1.41210ömillion),andangioedema01029.Thetimeofonsetofsystemicreactionsofimmediatetypewas30minin32cases2times,and1hand2hin6cases2times;thetimetoonsetoflateresponsetypewas3h48hin23cases2timeswithhighestincidenceofsevereasthmaticat2tacks.Thesystemicreactionsoccurredin18subjectsduringskintest,in96cases2timesduringincreasingdosephase,andin14cases2timesduring.Amongthem6caseswereofanaphylacticshock,andnoneofitafteremergencytreatment.Themajorcauseofmanifestationofsystemicreactionsfor41casesafterim2munotherapywithSMU2Dfextractwasduetooverdosageerrors.CONCLUSION:TheapplicationofSMU2Dfextractinskintestandimmunotherapyofasthmaandrhinitissensitivetomiteforthepast22yearsinthiscountryindicatedthattheefficacyandsafetyhavebeenhigh.Keywords:Dermatophagoidesfarinae,allergen,asthma,rhinitis,diagnosis,immunotherapy,safety3SupportedbytheNationalNaturalScienceFoundationofChina(No.39270638)672©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.