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毕业论文题目:红霉素类药物的研究概述系别:生物工程系专业:生物技术姓名:韩高丽学号:092407105指导教师:张现青河南城建学院2011年5月20日河南城建学院生物工程系毕业论文i目录摘要................................................IABSTRACT................................................II第一章前言..............................................41.1红霉素类药物概述..........................................................................41.2.红霉素类药物的功能........................................................................51.2.1红霉素类药物的药效学.............................................................51.2.2红霉素类药物的药动学.............................................................61.3红霉素类药物的研究意义...............................................................61.4红霉素类药物的最新研究现状.......................................................7第二章红霉素类药物的大规模生产.........................92.1红霉素生产的菌种............................................................................92.2.红霉素大规模生产的工艺流程....................................................92.2.1种子制备...................................................................................102.2.2制备培养基...............................................................................102.2.3灭菌............................................................................................132.2.4发酵............................................................................................132.2.5预处理.......................................................................................132.2.6分离............................................................................................132.2.7成盐............................................................................................142.2.8结晶............................................................................................14河南城建学院生物工程系毕业论文ii2.2.9抽滤............................................................................................142.2.10成品..........................................................................................142.2.11废液处理..................................................................................142.2.12红霉素母体的其它药物生产................................................15第三章红霉素类药物的国内外生产现状..........................................163.1国内主要生产现状.........................................................................163.2国外主要生产现状.........................................................................173.3红霉素生产中存在的问题.............................................................183.4关于红霉素生产的建议.................................................................18参考文献...........................................................20致谢............................................................22河南城建学院生物工程系毕业论文i摘要红霉素是世界抗生素市场上第三大类药物。目前全世界红霉素的主要生产国为美国、意大利、日本、法国、西班牙、葡萄牙、印度、波兰及中国。红霉素为大环内酯类抗生素,抗菌谱主要是对革兰式阳性菌如金葡菌、溶血性链球菌、肺炎球菌、白喉杆菌、炭疽杆菌及梭形芽胞杆菌等,均有强大抗菌作用。对革兰阴性菌如脑膜炎双球菌、淋球菌、百日咳杆菌、流感杆菌、布氏杆菌、部分痢疾杆菌及大肠杆菌等有一定作用。特点是对青霉素产生耐药性的菌株,对本品敏感。作用机制主要是与核糖核蛋白体的50S亚单位相结合,抑制肽酰基转移酶,影响核糖核蛋白体的移位过程,妨碍肽链增长,抑制细菌蛋白质的合成,系抑菌剂。国内生产红霉素类药物的厂家:西安利君制药股份有限公司、北京赛生药业有限公司等,其中西安利君制药股份有限公司可以说是生产红霉素类药物的龙头老大了,该公司的生产工艺成为红霉素类药物的典型代表,在文章中介绍类红霉素类药物的生产工艺流程。由于国外生产红霉素的历史比我国悠久,其产量远远超过我国,但是世界现在共同面临的问题是,红霉素的生产工艺过于老化,提取工艺也不够完善,所以现在世界各国都在寻求生产红霉素类药物的更完美的工艺,以及也在致力于研究红霉素产生菌的基因组,以便于改造工程菌,从而提高红霉素类药物生产产量。文章主要论述了,红霉素类药物的作用机理,红霉素类药物的大规模生产工艺流程,国内外生产水平,现在红霉素类药物研究中存在的问题及展望。关键词:红霉素抗菌谱青霉素革兰式阳性菌核糖核蛋白体河南城建学院生物工程系毕业论文iiABSTRACTErythromycinisthethirdcategoriesworldantibioticmarketdrugs.AtpresentthemainproducerintheworldforAmericanerythromycin,Italy,Japan,France,Spain,Portugal,India,PolandandChina.Erythromycinisthelargeringlactoneclassantibiotic,antibacterialspectrumismainlytotheleatherorchidtypepositivebacteriasuchasaureaus,hemolyticstreptococcus,pncumoniacoccus,diphtheriabacili,anthraxandspindlebacillustowait,allhavestrongantibacterialaction.Togram-negativebacteriasuchasmeningitisdiplococcus,drenchcoccus,whoopingcoughbacili,influenzae,brinellbacillus,partialdysenterybacillusande.coli,etchavecertaineffect.Characteristicsofresistanttopenicillinisthisproductstrains,sensitivity.MechanismmainlywiththeDNA50Ssubunitsnucleoproteinbodycombinedirus-inhibitorypeptideacyltransferenzyme,DNA,influencethenucleoproteinbodyshiftprocess,hinderpeptidegrowth,inhibitingbacterialproteinsynthesis,fastenbacteriostaticagent.DomesticproductionerythromycindrugsLiJunpharmaceuticalmanufacturer:xianajointstocklimitedcompany,BeijingbornpharmaceutcalCo.,etc,whichLiJunpharmaceuticalCo.,LTDinxiantosayistheproductionoferythromycindrugs,theleaderintheproductionprocessbecomesthetypicalrepresentativeoferythromycindrugs,inthearticleintroduceerythromycin-likedrugsproductionprocess.河南城建学院生物工程系毕业论文iiiBecauseforeignproductionthanmylonghistoryoferythromycin,itsyieldfarmorethanChina,buttheworldnowcommonproblemsfacingtheproductionprocess,erythromycin,extractiontechnologyalsotooagingarenotperfect,sonowcountriesintheworldtoseekdrugsproductionerythromycinmoreperfecttechnologyandalsoindedicatedtothestudyofthegenome,erythromycinproducebacteriainordertotransformengineeringbacterium,thusimproveerythromycindrugsproduction.Thisarticlemainlydiscussesthedrugs,erythromyc
本文标题:红霉素类药物的论文
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