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(,510632)R39218A10002484X(2004)062043520430,,[1],:,TDNA,,;,,IgE1111IgE1966,IgE,IgE,,FcIgEFc(FcRI),IL24IL213Th2BIgE[2]HIV21,HIVTh1Th2,Th2,IL24,IgE,112IgEFcRIIgEH()C1-4IgEFc2FcRI[3],FcRIIgEFc,C3,IgEFc,FcC2FcRI,IgEFc2I[2003]5(03166)(36708):(1978-),,;:(1952-),,,;Tel.[phone];E2mail:[e-mail][4]FcR2(1[5])IgE,FcRIFcRICITAM,SykFyn(PKA),(),2211,,IgG,IgG,IgE,60%90%,,,,,[6]212TT1FcRFig.1ThestructureofFcR5346T,T,T,BIgE[7]T,IgE,IgEFeldI()T,[8]TT,,T,T,[9]213,,[10],DNA,,Th21,Th22Th21Th21CpG[11],,(Hevb1)[12],,3311IL24,IL24FcRIFcRIII,IL213,IFN2IL24PIL213Hahn[13]OVABALBPC,IL24PIL213,IL25IL24CD4+T,IL24PIL213IL24(sIL24R),IL24,312IgEIgEFcIgE1988,Baniyash[14]IgEIgEFcRIIgEIgE3IgE,IgEFcRIFcRIIRudolf[15],IgEBSW17IgE,IgE,IgEIgE,IgEBmIgEC3,IgEBmIgE,IgEB,IgEHAMA,IgE,rhu2mAb2E25IgEIgEIgG1,,[16]rhu2mAb2E25E25E25IgE1%,FcRI[17]313IgE[18]IgETNX-901,IgE,IgE,IgEFc,IgEF1Kricek[19]IgEBSW17615,BSW17,FcC3(370375)C4(500508),(KLH),IgE,BSW17,IgE,,,(PCA),PCAChangYiWang[20]C3413435,(Th,),(IgE),BALBPC,IgEIgEFcRIIgE634200420PCA,,IgE,IgE,Vogel[21]BSW17Fab,,BSW17,IgE,IgEBSW17Fab314FcRIFcRI,,FcRIIgE,[22]FcRIBIgE(mIgE),FcRIIgE[23]FcRIFcRI,FcRI,,FcRI,[24]4,,,,,,,,,(),Westernblot2ting,IgE,,,[25],,,,,IgE,()IgEFcFcR,,,,,,,IgE,51StrannegardO,StrannegardIL.Thecausesoftheincreasingprevalenceofallergy:isatopyamicrobialdeprivationdisorder[J].Allergy,2001;56:912102.2PatellaV,FlorioG,PetraroliAetal.HIV21gp120inducesIL24andIL213releasefromhumanFcRI+cellsthroughinteractionwiththeVH3regionofIgE[J].JImmunol,2000;164(2):5892595.3GarmanSC,WurzburgBA,TarchevskayaSSetal.StructureoftheFcfragmentofhumanIgEboundtoitshigh2affinityreceptorFcRI[J].Nature,2000;406(6793):2592266.4McDonnellJM,CalvertR,BeavilRLetal.ThestructureoftheIgECepsilon2domainanditsroleinstabilizingthecomplexwithitshigh2af2finityreceptorFcepsilonRIalpha[J].NatStructBiol,2001;8(5):4372441.5HolgateST.Asthmaandallergydisordersofcivilization[J]?QJM,1998;91:7172184.6RudolfV.Thefutureofantigen2specificimmunotherapyofallergy[J].Nature,2002;6(2):4462453.7YsselH,FaslerS,LambJetal.Inductionofnon2responsivenessinhu2manallergenspecifictype2Thelpercells[J].CurrOpinImmunol,1994;6:8472852.8OshibaA,HamelmannE,BradleyKLetal.Pretreatmentwithallergenpreventsimmediatehypersensitivityandairwayhyperresponsiveness[J].AmJRespirCritCareMed,1996;153:1022109.9SchrammG,KahlertH,SuckRetal.Allergenengineering:variantsofthetimothygrasspollenPh1p5bwithreducedIgE2bindingcapacitybutconservedTcellreactivity[J].JImmonuol,1999;162(4):240622414.10KrishnenduR,MaoHQ,HuangSKetal.Oralgenedeliverlywithchitosan2DNAnanoparticlesgeneratesimmunologicprotectioninamu2rinemodelofpeanutallergy[J].NatureMedicine,1999;5(4):3872391.11SpiegelbergHL,RazE.DNA2basedapproachestothetreatmentofal2lergies[J].CurrOpinMolTher,2002;4(1):64271.12StaterJE,PauporeE,ZhangYTetal.ThelatexallergenHevb5transcriptiswidelydistributedaftersubcutaneousinjectioninBALBPCmiceofitsDNAvaccine[J].JAllergyClinImmunol,1998;102:4692475.13Li2WeberM,KrammerPH.RegulationofIL24geneexpressionbyTcellsandtherapeuticperspectives[J].NatRevImmunol,2003;3(7):5342543.14BaniyashM,KehryM,EshharZ.Anti2IgEmonoclonalantibodiesdi2rectedattheFcepsilonreceptorbindingsite[J].MolImmunol,1988;25:7052711.15RudolfMP,FurukawaK,MiescherSetal.Effectofanti2IgEantibod2iesonFcepsilonRI2boundIgE[J].JImmunol,1996;157:5646273465652.16CasaleTB,BernsteinIL,BusseWWetal.Useofananti2IgEhu2manizedmonoclonalantibodyinragweed2inducedallergicrhinitis[J].JAllergyClinImmunol,1997;100:1102121.17MacGlashanJr,DW,BochnerBS,AdelmanDCetal.Down2regula2tionofFc(epsilon)RIexpressiononhumanbasophilsduringinvivotreatmentofatopicpatientswithanti2IgEantibody[J].JImmunol,1997;158:143821445.18LeungDYM,SampsonHA,YungingerJWetal.Effectofanti2IgEtherapyinpatientswithpeanutallergy[J].NEnglJMed,2003;348:9862993.19KricekF,RufC,RuddofMPetal.IgE2relatedpeptidemimotope:Basicstructuresforantiallergyvaccinedevelopment[J].IntArchAller2gyImm,1999;188:2222223.20WangCY,WalfieldAM,FangXDetal.SyntheticIgEpeptidevac2cineforimmunotherapyofallergy[J].Vaccine,2003;21:158021590.21VogelM,MiescherS,KuhnSetal.MimicryofhumanIgEepitopesbyanti2idiotypicantibodies[J].JMolBiol,2000;298:7292735.22Haak2FrendschoM,RidgwayJ,ShieldsRetal.HumanIgEreceptor2chainIgGchimerablockspassivecutaneousanaphylaxisreactioninvi2vo[J].JImmunol,1993;151:3512358.23YanagiharaY,KajiwaraK,IkiazawaKetal.Recombinantsolubleformofthehumanhigh2affinityimmunoglobulinE(IgE)receptorinhib2itsIgEproductionthroughitsspecificbindingtoIgE2bearingBcells[J].AmSocClinInv,1994;94:216222165.24MenachemR.Chronicurticariaandautoimmunethyroiddisease:istherealink[J].AutoimmunityReview,2003;2:69279.25HillerR,LafferS,HarwaneggCetal.Microarrayedallergenmole2cules:diagnosticgatekeepersforallergytreatment[J].FASEBJ,2002;16:4142416.[20032092212003212224]()(434),GDIGF21,BMD,IGF21BMD,GDIGFPIGFBPs,IGFBPs,IGF21,IGF21,IGF21,[1];GDTH,,,[7],FT4BMD,FT4,GD,,IGF21,,BMD,BMD,IGF21,GD,BMD,,IGF21,,41LakatosP,FoldesJ,NagyZetal.Seruminsulin2likegrowthfactor2I,in2sulin2likegrowthfactorbindingproteins,andbonemineralcontentinhy2perthyroidi