包尚联ICMIP-XXXX全体会议的发言

PresentandFutureofMedicalImagingPhysics包尚联ShanglianBao北京大学医学物理和工程北京市重点实验室BeijingKeyLabofMedicalPhysics&Engineering北京大学肿瘤物理诊疗技术研究中心[e-mail]2019/9/131ICMIP-2013沈阳Basicdisciplinesofhealthprotection•Physics，Chemistry&informaticsSafeguardhumanhealth•Solveproblemfromoriginalrequirement2019/9/13ICMIP-2009沈阳2Goal:getenoughVivostateinformationbyNon-invasivemedicalimagingmeansincludingmolecular，cell，organandsystemformorphological,physiologicalandpsychologicalinformationinprecise,accuracy2019/9/13ICMIP-2013沈阳3Physics&EngineeringofMedicalImaging•MedicalImagingPhysics–Principleandprototypedevice•MedicalImagingEngineering–Industrydeviceandproduction•Bothdoapplicationinclinical–diseaseDiagnosis–diseasetherapeutics–Datatreatmentandanalysis–Verificationandguarantee4MajorModalities•X-rayImaging(animal&humanimaging)–Planer:DR,CR–Tomography:spiralCT,ConeBeanCT•NMI(animal&humanimaging)–SPECT:combiningwithCT–PET:combiningwithCT•MRI(animal&humanimaging)–Middle，high&Extrahighfieldsystem;•UltrasoundI–3D,4Dimaging–Generalandspecial2019/9/13ICMIP-2013沈阳4EssentialTask•Allplaces×needtoextendthehumaneyecapability，Accompanyinghumandevelopment–AfterMacroscopicinformation，Microscopicinformationmoreimportant；–Aftermorphology，physiologymoreimportant；–Aftereyevisibleinformation,eyeinvisibleinformationismoreimportant,includingphysiologyandpsychology.2019/9/13ICMIP-2013沈阳52019/9/136FrontDirection:MolecularImaging•Permanenttopic：Newgeneticmaterialandproteins–Accompanyingtheprogressofmankind–Revealingessentialpathologicalreason–Veryearlier(sufficienttimetoadjustandtreatment)ICMIP-2013沈阳2019/9/137mRNADNARNA酶的合成和活性调控物转运蛋白RNA结合物报告探针报告基因DNAAATglut4代谢产物MAb激素配体缩氨酸DNA合成物+othermoleculesAllindynamicaland3DdistributionICMIP-2013沈阳Twomostimportantmolecules•Newgeneticmaterial–Humanevolutionfasterthanbefore(naturalandartificial)•Nature：changesonbiodiversity,climaticconditions,foodchain,speedofmixedracegene•Artificial：Newgeneticmodificationofplantsandanimals，evenhuman•Proteins–HumanProgressrelyonproteinsandnewproteins–2019/9/13ICMIP-20139沈阳8GeneMutation•Goodgenemutation–Promotinghumanprogress•Badgenemutation–Causediseases,suchascancer•Variousdiseases,e.g.cancer，cardiovascular&braindiseasesincreasing•EveryIndividual：progressivedisease，whichisgeneticallydetermined2019/9/13ICMIP-2013沈阳9突变,超量表达基因,抗原产生抗体生物标志物遗传病毒感染化学致癌物辐射致癌物老化其他血液中相应抗体Cancergeneticmaterialencodingtheproteinmarkers用载体克隆基因克隆表达,基因和载体蛋白克隆筛选得到癌症相关克隆OtherMolecules•Suchas–Metabolites，Hormones，Neurotransmitters•Mainlydeterminedbyacquiredenvironmental–WhichwereworsethanbeforeinChina,whichdependenceonhealthcare•newchallengesforhealthworkers–Medicalphysicists&physicians–Engineersandothers2019/9/13ICMIP-2013沈阳11Complexity&hugenumber•Moleculesinvivo–Hugenumbers：constructorbody,keepstablerunning,maintainvitalityofcellsandhuman–Complexity•MultipleStructures&multiplefunctions•Differentrolesindifferentprocess•Dynamicalchanges2019/9/13ICMIP-2013沈阳12NewTasksonDevicesandProbes•Devices–Creativenewmeasuringimagingdevices–Multiplemodalityintegration–Comprehensivedataanalysisandprocessing•Probes–Coveringallkindofmolecules–MethodologiesonSynthesis,labelingandtesting–Probesfornewmodalities，e.g.forMRI2019/9/13ICMIP-2013沈阳13MolecularNuclearMedicalImaging•Traditionalmolecularimaging–PET，SPECT&theircombinationwithCT,MRI–Developedasufficientnumberofbiologicalprobes–Routineclinicaldiagnostictool•Disadvantage–Poorspaceandtimeresolutions–TakethemasanatomicsourceonlyusingtheirWeakness•WhynodynamicalanalysisinChina–Notimetosatisfysomanypatients–Nospecialisttodotheanalysis–Nooriginalcreativeresearch(includingthedrugD)2019/9/13ICMIP-2013沈阳14•2001，firstInter.ConferenceinmolecularimaginginBoston•2002,May,Nature:VasilisNtziachristosetal:Fluorescencemoleculartomographyresolvesproteaseactivityinvivo•2002,OctoberMr.TangXiaoweiholdtheXiangshanScienceSymposiuminHangZhou,Title:Molecularmedicalimaging.•Endof2002，Basedimagingmeasurements(includingopticalimaging)ofthedynamicsofmolecularandcellulareventsVisualization,Science:Oneofthetoptenbreakthroughs•2006,973subjectonmoleculariamgingsetup,TianJie,BaiJingandBaoShanglian•2011,continued分子影像学国内外研究现状和发展趋势—综述•Diagnosisinearlierstage,distinguishBenignandmalignanttumors；•Developnewdrugs：Pharmacology,toxicity,andinvivostability,includingtheprobes•Testingthedynamicalanalysismodel•QuantitativeparametersinparameterimagingSignificantofDynamicalMolecularImaging01530456075900102030405060708090Concentrationofauthentictracer(kBq/mL)Time(min)01530456075900102030405060708090Concentrationintissue(kBq/mL)Time(min)”input””output”AuthentictracerconcentrationavailableinarterialbloodConcentrationintissuemeasuredbyPETscannerPerfusionEndothelialpermeabilityVascularvolumefractionTransportacrosscellmembranesSpecificbindingtoreceptorsNon-specificbindingEnzymeactivityPrincipleparametricimage：–Perfusion(mLblood)/(minxmLtissue)–Glucoseuptakerate(µmolglucose)/(minxmLtissue)–Bindingpotential(B’max/Kd)BLOODorPLASMATACTISSUETAC-sinogramor-imageor-regionalRESULT